Research mission

The Laboratory of Pathophysiology:
a translational research platform in cell death, inflammation and disease.

fundamental, preclinical and clinical research

The Laboratory of Pathophysiology is a multidisciplinary team performing basic as well as applied research on mechanisms, treatment and prevention of disease. We offer an integrated approach from animal studies and cell culture to preclinical and clinical trials, support and consultancy.

Research focus

  • Study of mechanisms, diagnostics and intervention strategies in the field of chronic kidney disease, vascular calcification and bone metabolism, and their interplay.
    Spokesperson Prof. Patrick D’Haese
  • Study of mechanisms, diagnostics and intervention strategies for cell death and inflammation in critical care (sepsis and multiple organ dysfunction syndrome) and brain injuries (multiple sclerosis, ischemic and hemorrhagic brain stroke).
    Spokesperson Prof. Tom Vanden Berghe
  • Study of targeting of ferroptosis in a therapy-resistant cancer in young children (neuroblastoma) using nanomedicine.
    Spokesperson Prof. Tom Vanden Berghe

‚ÄčResearch topics 2019: kidney, vessels and bone

    Cell cycle control during renal repair
in acute / chronic kidney disease
    Cell biology of renal regeneration
    Mechanisms and treatment of vascular media calcification
    Molecular mechanisms underlying vessel stiffening
  The calcification paradox: how to treat bone disease without inducing vascular calcification?
  Wnt β-catenin inhibitors (sclerostin, DKK-1): their role in mineral metabolism?
  Status / evolution of renal bone disease / osteoporosis
Study of the cardiorenal syndrome
Drug-induced (side) effects on mineral metabolism/kidney function by:
- phosphate binding agents
- calcimimetics
- calcification inhibitors
- anti-diabetic agents: DPP4 inhibitors, metformin
- anti-viral agents